diff --git a/src/intel/compiler/brw/brw_lower_regioning.cpp b/src/intel/compiler/brw/brw_lower_regioning.cpp
index e931ac73007..3ad93762242 100644
--- a/src/intel/compiler/brw/brw_lower_regioning.cpp
+++ b/src/intel/compiler/brw/brw_lower_regioning.cpp
@@ -452,8 +452,16 @@ namespace {
       switch (inst->opcode) {
       case BRW_OPCODE_MOV:
          return false;
-      case BRW_OPCODE_SEL:
-         return inst->dst.type != get_exec_type(inst);
+      case BRW_OPCODE_SEL: {
+         const brw_reg_type exec_type = get_exec_type(inst);
+
+         if (inst->dst.type == exec_type)
+            return false;
+
+         /* SEL can mix integer sizes and signed/unsigned. */
+         return !brw_type_is_int(inst->dst.type) ||
+                !brw_type_is_int(exec_type);
+      }
       default:
          /* FIXME: We assume the opcodes not explicitly mentioned before just
           * work fine with arbitrary conversions, unless they need to be
diff --git a/src/intel/compiler/brw/meson.build b/src/intel/compiler/brw/meson.build
index 88d42fe6648..f96ea1b2650 100644
--- a/src/intel/compiler/brw/meson.build
+++ b/src/intel/compiler/brw/meson.build
@@ -163,6 +163,7 @@ if with_tests
         'test_helpers.cpp',
         'test_helpers.h',
         'test_insert_load_reg.cpp',
+        'test_lower_regioning.cpp',
         'test_lower_scoreboard.cpp',
         'test_opt_algebraic.cpp',
         'test_opt_cmod_propagation.cpp',
diff --git a/src/intel/compiler/brw/test_lower_regioning.cpp b/src/intel/compiler/brw/test_lower_regioning.cpp
new file mode 100644
index 00000000000..a0cfe82da02
--- /dev/null
+++ b/src/intel/compiler/brw/test_lower_regioning.cpp
@@ -0,0 +1,24 @@
+/*
+ * Copyright © 2025 Intel Corporation
+ * SPDX-License-Identifier: MIT
+ */
+
+#include "test_helpers.h"
+#include "brw_builder.h"
+
+class lower_regioning_test : public brw_shader_pass_test {
+};
+
+TEST_F(lower_regioning_test, sel_ud_d_d)
+{
+   brw_builder bld = make_shader();
+
+   brw_reg dest = vgrf(bld, BRW_TYPE_UD);
+   brw_reg src0 = vgrf(bld, BRW_TYPE_D);
+   brw_reg src1 = vgrf(bld, BRW_TYPE_D);
+
+   bld.SEL(dest, src0, src1)
+      ->saturate = true;
+
+   EXPECT_NO_PROGRESS(brw_lower_regioning, bld);
+}