diff --git a/src/amd/compiler/aco_optimizer.cpp b/src/amd/compiler/aco_optimizer.cpp
index 2f78631cde8..46746aea4e0 100644
--- a/src/amd/compiler/aco_optimizer.cpp
+++ b/src/amd/compiler/aco_optimizer.cpp
@@ -4979,6 +4979,9 @@ select_instruction(opt_ctx& ctx, aco_ptr<Instruction>& instr)
       for (unsigned i = 0; i < input_info.operands.size(); i++) {
          if (!input_info.operands[i].op.isTemp())
             continue;
+         /* Applying DPP with many uses is unlikely to be profitable. */
+         if (ctx.uses[input_info.operands[i].op.tempId()] > 3)
+            continue;
          Instruction* parent = ctx.info[input_info.operands[i].op.tempId()].parent_instr;
 
          if (!parent->isDPP() || parent->opcode != aco_opcode::v_mov_b32 ||
diff --git a/src/amd/compiler/aco_optimizer_postRA.cpp b/src/amd/compiler/aco_optimizer_postRA.cpp
index c5e45e0ea0e..77d04c6ccd4 100644
--- a/src/amd/compiler/aco_optimizer_postRA.cpp
+++ b/src/amd/compiler/aco_optimizer_postRA.cpp
@@ -612,6 +612,10 @@ try_combine_dpp(pr_opt_ctx& ctx, aco_ptr<Instruction>& instr)
       if (mov->opcode != aco_opcode::v_mov_b32 || !mov->isDPP())
          continue;
 
+      /* Applying DPP with many uses is unlikely to be profitable. */
+      if (ctx.uses[mov->definitions[0].tempId()] > 3)
+         continue;
+
       /* If we aren't going to remove the v_mov_b32, we have to ensure that it doesn't overwrite
        * it's own operand before we use it.
        */