diff --git a/cmake/ConfigureChecks.cmake b/cmake/ConfigureChecks.cmake
index 737913ba..b138b367 100644
--- a/cmake/ConfigureChecks.cmake
+++ b/cmake/ConfigureChecks.cmake
@@ -72,6 +72,22 @@ check_symbol_exists(socketpair   "sys/socket.h"     HAVE_SOCKETPAIR)         #
 check_symbol_exists(unsetenv     "stdlib.h"         HAVE_UNSETENV)           #  dbus-sysdeps.c
 check_symbol_exists(writev       "sys/uio.h"        HAVE_WRITEV)             #  dbus-sysdeps.c, dbus-sysdeps-win.c
 
+# It doesn't really matter which specific header we use for these, as long as
+# we include at least one glibc-provided header. time.h is suitable.
+check_symbol_exists(__GLIBC__    "time.h"                    HAVE___GLIBC__)
+check_symbol_exists(_FILE_OFFSET_BITS "time.h"               HAVE__FILE_OFFSET_BITS)
+check_symbol_exists(_TIME_BITS   "time.h"                    HAVE__TIME_BITS)
+
+# Opt-in to large inode number and timestamp support, which we know doesn't
+# break libdbus ABI: https://gitlab.freedesktop.org/dbus/dbus/-/issues/465
+if(HAVE___GLIBC__ AND CMAKE_SIZEOF_VOID_P EQUAL 4 AND NOT HAVE__FILE_OFFSET_BITS)
+    set(_FILE_OFFSET_BITS 64)
+endif()
+
+if(HAVE___GLIBC__ AND CMAKE_SIZEOF_VOID_P EQUAL 4 AND NOT HAVE__TIME_BITS)
+    set(_TIME_BITS 64)
+endif()
+
 check_struct_member(cmsgcred cmcred_pid "sys/types.h;sys/socket.h" HAVE_CMSGCRED)   #  dbus-sysdeps.c
 
 CHECK_C_SOURCE_COMPILES("
diff --git a/cmake/config.h.cmake b/cmake/config.h.cmake
index e16d2247..16e737f3 100644
--- a/cmake/config.h.cmake
+++ b/cmake/config.h.cmake
@@ -13,6 +13,8 @@
 #   define __USE_MINGW_ANSI_STDIO 0
 #endif
 
+#cmakedefine _FILE_OFFSET_BITS @_FILE_OFFSET_BITS@
+#cmakedefine _TIME_BITS @_TIME_BITS@
 #cmakedefine WORDS_BIGENDIAN
 
 /* Opt-in to modern APIs and thread-safety for Solaris. In the Autotools
diff --git a/configure.ac b/configure.ac
index b1809e75..389b2796 100644
--- a/configure.ac
+++ b/configure.ac
@@ -546,6 +546,31 @@ fi
 
 AC_SUBST(DBUS_INT16_TYPE)
 
+# Opt-in to large timestamp support, which we know doesn't break libdbus ABI:
+# https://gitlab.freedesktop.org/dbus/dbus/-/issues/465
+# Currently we only know how to do this for GNU libc.
+AC_CHECK_DECL(
+    [__GLIBC__], [
+        AC_CHECK_DECL(
+            [_TIME_BITS],
+            [time_bits_defined=yes],
+            [time_bits_defined=no],
+            [[#include <time.h>]]
+        )
+    ],
+    [],
+    [[#include <time.h>]]
+)
+AS_IF(
+    [test "$time_bits_defined" = no && test "$DBUS_SIZEOF_VOID_P" = 4],
+    [
+        AC_DEFINE(
+            [_TIME_BITS], [64],
+            [Define to 64 if using 32-bit glibc and not already defined]
+        )
+    ]
+)
+
 ## byte order
 case $host_os in
 	darwin*)
diff --git a/meson.build b/meson.build
index 9bfcb4a8..4fef6100 100644
--- a/meson.build
+++ b/meson.build
@@ -627,6 +627,17 @@ endif
 config.set('DBUS_BUILD_X11', use_x11_autolaunch)
 config.set('DBUS_ENABLE_X11_AUTOLAUNCH', use_x11_autolaunch)
 
+# Opt-in to large timestamp support, which we know doesn't break libdbus ABI:
+# https://gitlab.freedesktop.org/dbus/dbus/-/issues/465
+# Meson does the equivalent for large offsets and inode numbers automatically.
+if (
+    cc.has_header_symbol('time.h', '__GLIBC__', args: compile_args_c)
+    and not cc.has_header_symbol('time.h', '_TIME_BITS', args: compile_args_c)
+    and cc.sizeof('void *') == 4
+)
+    config.set('_TIME_BITS', '64')
+endif
+
 # keep CMakeLists.txt in sync
 check_functions = [
     'accept4',