diff --git a/.gitlab-ci/run-test.sh b/.gitlab-ci/run-test.sh
index 50d0903619..758b8ada05 100755
--- a/.gitlab-ci/run-test.sh
+++ b/.gitlab-ci/run-test.sh
@@ -61,7 +61,6 @@ check_run_assert() {
         meson+gcc+docs+valgrind
         autotools+clang
         meson+clang
-        autotools+gcc+docs+el7+py2
         rpm+autotools
         rpm+meson
         tarball
@@ -118,8 +117,6 @@ check_run_clean meson+gcc+docs+valgrind && BUILD_TYPE=meson     CC=gcc   WITH_DO
 check_run_clean autotools+clang         && BUILD_TYPE=autotools CC=clang WITH_DOCS=0                 contrib/scripts/nm-ci-run.sh
 check_run_clean meson+clang             && BUILD_TYPE=meson     CC=clang WITH_DOCS=0                 contrib/scripts/nm-ci-run.sh
 
-check_run_clean autotools+gcc+docs+el7+py2 && test $IS_CENTOS_7 = 1 && PYTHON=python2 BUILD_TYPE=autotools CC=gcc WITH_DOCS=1 contrib/scripts/nm-ci-run.sh
-
 check_run_clean rpm+autotools && test $IS_FEDORA = 1 -o $IS_CENTOS = 1 && ./contrib/fedora/rpm/build_clean.sh -g -w crypto_gnutls -w debug -w iwd -w test -W meson
 check_run_clean rpm+meson     && test $IS_FEDORA = 1                   && ./contrib/fedora/rpm/build_clean.sh -g -w crypto_gnutls -w debug -w iwd -w test -w meson
 
diff --git a/NEWS b/NEWS
index e7838bd35f..cd46906b50 100644
--- a/NEWS
+++ b/NEWS
@@ -10,6 +10,7 @@ Overview of changes since NetworkManager-1.44
   link local addresses on default wired connection.
 * Honor udev property ID_NET_MANAGED_BY to only manage an interface
   when set to "org.freedesktop.NetworkManager".
+* Drop build support with Python2. Python3 is now required.
 
 =============================================
 NetworkManager-1.44
diff --git a/contrib/fedora/rpm/NetworkManager.spec b/contrib/fedora/rpm/NetworkManager.spec
index afc7e8ee14..db07a30ac7 100644
--- a/contrib/fedora/rpm/NetworkManager.spec
+++ b/contrib/fedora/rpm/NetworkManager.spec
@@ -303,21 +303,10 @@ BuildRequires: mobile-broadband-provider-info-devel
 BuildRequires: newt-devel
 %endif
 BuildRequires: /usr/bin/dbus-launch
-%if 0%{?fedora} >= 28 || 0%{?rhel} >= 8
 BuildRequires: python3
 BuildRequires: python3-gobject-base
 BuildRequires: python3-dbus
 BuildRequires: python3-pexpect
-%else
-BuildRequires: python2
-BuildRequires: pygobject3-base
-BuildRequires: dbus-python
-BuildRequires: pexpect
-%if 0%{?rhel} >= 7 && %{with meson}
-BuildRequires: python36-dbus
-BuildRequires: python36-gobject
-%endif
-%endif
 BuildRequires: libselinux-devel
 BuildRequires: polkit-devel
 BuildRequires: jansson-devel